H2N2V1, Main, Exploration, bibRecord, 001D97

Multidose, Live Attenuated, Cold-Recombinant, Trivalent Influenza Vaccine in Infants and Young Children

Identifieur interne : 001D97 ( Main/Exploration ); précédent : 001D96; suivant : 001D98

Multidose, Live Attenuated, Cold-Recombinant, Trivalent Influenza Vaccine in Infants and Young Children

Auteurs : Ella M. Swierkosz [États-Unis] ; Frances K. Newman [États-Unis] ; Edwin L. Anderson [États-Unis] ; Sharon L. Nugent [États-Unis] ; Gretel B. Mills [États-Unis] ; Robert B. Belshe [États-Unis]

Source :

Journal of Infectious Diseases [ 0022-1899 ] ; 1994.

RBID : ISTEX:130B9A78B27AB0205A0F77A67C7410FCA1832588

Abstract

Twenty-two healthy infants and children received either cold-recombinant, trivalent influenza vaccine or placebo in a three-dose vaccine trial. Most (82%) who received vaccine were seronegative to all three vaccine strains (106 TCID50/dose each): A/Kawasaki/9/86 (H1N1), A/Los Angeles/2/87 (H3N2), and B/Yamagata/16/88. Vaccine was administered intranasally at time 0 and 2 and 4 months later. The vaccine was well tolerated and immunogenic when administered in a multidose regimen. The first dose stimulated antibody to H1, H3, and Bin 59%, 94%, and 35% of vaccinees, respectively, by hemagglutination inhibition (HAI) or ELISA. After two doses of vaccine, 93%, 93%, and 80% had antibody by HAI or ELISA to H1, H3, and B, respectively. Most vaccinees (67%) responded to all three viruses after two doses of vaccine. The third dose contributed little to the vaccine's immunogenicity. Multidose trivalent influenza vaccine is safe and induces an immune response in most vaccinees after two doses.

Url:

https://api.istex.fr/ark:/67375/HXZ-D1B4ZG7F-Q/fulltext.pdf

DOI: 10.1093/infdis/169.5.1121

Affiliations:

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Le document en format XML

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<front><div type="abstract">Twenty-two healthy infants and children received either cold-recombinant, trivalent influenza vaccine or placebo in a three-dose vaccine trial. Most (82%) who received vaccine were seronegative to all three vaccine strains (106 TCID50/dose each): A/Kawasaki/9/86 (H1N1), A/Los Angeles/2/87 (H3N2), and B/Yamagata/16/88. Vaccine was administered intranasally at time 0 and 2 and 4 months later. The vaccine was well tolerated and immunogenic when administered in a multidose regimen. The first dose stimulated antibody to H1, H3, and Bin 59%, 94%, and 35% of vaccinees, respectively, by hemagglutination inhibition (HAI) or ELISA. After two doses of vaccine, 93%, 93%, and 80% had antibody by HAI or ELISA to H1, H3, and B, respectively. Most vaccinees (67%) responded to all three viruses after two doses of vaccine. The third dose contributed little to the vaccine's immunogenicity. Multidose trivalent influenza vaccine is safe and induces an immune response in most vaccinees after two doses.</div>
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Multidose, Live Attenuated, Cold-Recombinant, Trivalent Influenza Vaccine in Infants and Young Children

Multidose, Live Attenuated, Cold-Recombinant, Trivalent Influenza Vaccine in Infants and Young Children

Source :

Abstract

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